Acute Promyelocytic Leukemia Associated with Hypofibrinogenemia

Acute promyelocytic leukemia associated with hypofibrinogenemia.

APROMYELOCYTOID” bone marrow and disturbances in fibrinogen are prominent features of a form of leukemia which is characterized by a rapid course, severe hemorrhage and poor response to therapy. This study is based upon 17 patients observed over the past 9 years. The first seven patients in this series were the basis of a brief report’ in 1955 of the occurrence of hypofibrinogenemia in acute le...

Immunophenotypes and Immune Markers Associated with Acute Promyelocytic Leukemia Prognosis

CD2+, CD34+, and CD56+ immunophenotypes are associated with poor prognoses of acute promyelocytic leukemia (APL). The present study aimed to explore the role of APL immunophenotypes and immune markers as prognostic predictors on clinical outcomes. A total of 132 patients with de novo APL were retrospectively analyzed. Immunophenotypes were determined by flow cytometry. Clinical features, comple...

Reassessing the hemostatic disorder associated with acute promyelocytic leukemia.

Acute myeloid leukemia and acute promyelocytic leukemia.

The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as the influx of investigational approaches and novel...

Acute myeloid leukemia pretreated with filgrastim mimicking acute promyelocytic leukemia.

A 66-year-old man with a history of hepatitis C virus and liver transplantation presented to the emergency department for shortness of breath. He had received weekly filgrastim for chronic neutropenia, and immediately before admission he had received 3 days of filgrastim and 1 day of pegfilgrastim. A hemogram showed a white blood cell count of 4.54 K/mL with 23% blastic cells. Emergent bone mar...